Fig. 1

Schematic of human FOXC1, zebrafish foxc1a and foxc1b loci, and developed zebrafish lines. A Schematic drawing of human chromosome 6 aligned with zebrafish chromosomes 2 and 20 showing the positions of the identified conserved elements (filled orange boxes labeled at the top). Exons are indicated with labeled black boxes, while intergenic and intronic regions are shown with dotted lines. Position of rs2745572[A], an SNP associated with primary open-angle glaucoma, is shown in blue on human chromosome 6 and corresponding intergenic regions on zebrafish chromosomes 2 and 20 are marked with blue rectangles. B Schematic drawing showing generated lines and corresponding genomic deletions (sequence gaps are indicated)