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FIGURE 3

ID

ZDB-FIG-221018-154

Publication

Son et al., 2022 - Hypoplasia of dopaminergic neurons by hypoxia-induced neurotoxicity is associated with disrupted swimming development of larval zebrafish

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FIGURE 3

(A) A schematic drawing (left, top panel) and Z-stack confocal image (left, bottom panel) of diencephalic TH⁺ DA neurons at 5 dpf, including in DC1, DC2, DC3, DC4/5, and DC6. (A) Z-stack confocal images of the anti-TH immunohistochemistry were analyzed in the DC4/5 and DC 6 areas (180.11 ?m � 180.11 ?m � 20 ?m) in HR zebrafish (n = 23) compared to normoxic controls (n = 20) analyzed with Student?s t-test and presented as Means � SEM. ***p < 0.001. (B) Developmental hypoxia results in disrupted swimming maturation at 6 dpf. Data plots (Means � SEM) show the averaged swimming distance, velocity, and frequency of movements n the dark (3 � 10 min) and in light (3 � 10 min) in HR larvae (n = 24) compared to normoxic controls (n = 24). Student?s t-test, ***p < 0.001, and *p < 0.05. (C) Developmental hypoxia causes reduced swimming distance in dark in 1.5-month-old young zebrafish (hypoxia, n = 6 vs. normoxia, n = 6). ***p < 0.001, *p < 0.05.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.