ZFIN Image: Son et al., 2022, FIGURE 3

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Figure Caption

FIGURE 3

(A) A schematic drawing (left, top panel) and Z-stack confocal image (left, bottom panel) of diencephalic TH⁺ DA neurons at 5 dpf, including in DC1, DC2, DC3, DC4/5, and DC6. (A) Z-stack confocal images of the anti-TH immunohistochemistry were analyzed in the DC4/5 and DC 6 areas (180.11 ?m � 180.11 ?m � 20 ?m) in HR zebrafish (n = 23) compared to normoxic controls (n = 20) analyzed with Student?s t-test and presented as Means � SEM. ***p < 0.001. (B) Developmental hypoxia results in disrupted swimming maturation at 6 dpf. Data plots (Means � SEM) show the averaged swimming distance, velocity, and frequency of movements n the dark (3 � 10 min) and in light (3 � 10 min) in HR larvae (n = 24) compared to normoxic controls (n = 24). Student?s t-test, ***p < 0.001, and *p < 0.05. (C) Developmental hypoxia causes reduced swimming distance in dark in 1.5-month-old young zebrafish (hypoxia, n = 6 vs. normoxia, n = 6). ***p < 0.001, *p < 0.05.

Acknowledgments

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