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Fig. 6

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ZDB-FIG-220921-128

Publication

Andreassen et al., 2022 - Brain dysfunction during warming is linked to oxygen limitation in larval zebrafish

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Fig. 6

Oxygen availability affects the sensory-response resilience to heating. (A) Mean fluorescence image of the brain (dashed gray line) of an agar-embedded, Tg(elavl3:GCaMP6s) 5-d-old fish under an epifluorescence microscope (same setup as in Fig. 5B). A, anterior; L, lateral. (B) Representative light response to a red-light flash specifically activating the optic tecti in the same fish as in A. (C) Percentage of responses to light flashes in the optic tectum during heat ramping with water oxygen level of 60% (hypoxia; magenta circles; n = 14), 100% (normoxia; black circles; n = 11), or 150% (hyperoxia; cyan circles; n = 13) of air-saturated water (Methods) (SI Appendix, Table S10). Temp, temperature.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA