FIGURE

Figure 12

ID

ZDB-FIG-220829-110

Publication

Copeland et al., 2022 - Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model

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Figure 12

Partial apex resection surgery at 0 days and heart explanted at 5D PO (A–C)—(A) Gross necropsy heart obtained five days post-operation (5D PO) from piglet #004. Note partially filled surgical defect (blue arrow) (Scale bar = 1 cm). (B) Hematoxylin and Eosin (H & E) histology (piglet #004) reveals a densely packed population of streaming cells in register with peripheral myocardium and with similar slightly larger elongate often plump nuclei (Scale bar = 20 μm). (C) H & E histology (piglet #004) of the marginal zone of proliferative cells has a mitotic figure of a cell identifiable as a cardiomyocyte based on straplike morphology, eosinophilic cytoplasm, and cross striations (black arrows) (Scale bar = 20 μm). Partial apex resection surgery at 0 days and heart explanted at 5D PO (D–F)—(D) Gross necropsy heart obtained five days post-operation (5D PO) from piglet #015. Note partially filled surgical defect (blue arrow) (Scale bar = 1 cm). (E) H & E histology (piglet #015) reveals a population of similar streaming elongate cells with elongate nuclei. (F) Masson’s trichrome stain (piglet #015) reveals a moderate intervening collagenous matrix.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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