FIGURE

Fig. 5

ID

ZDB-FIG-220810-21

Publication

Chen et al., 2022 - Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio)

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Fig. 5

a Experimental setup. b, d Light-sheet imaging showed an increased number and percentage of the colocalization of coro1a?+?leukocytes and AO?+?apoptotic cells in the zebrafish brain at 4 dpt. Independent t test, **, p?<?0.01 compared with CTRL. c, e Light-sheet imaging showed an increased number of AO?+?apoptotic cells in the zebrafish brain at 1 dpt but not at 2 dpt. Independent t test, **, p?<?0.01 compared to CTRL. f Light-sheet imaging showed that mpeg1?+?macrophages returned to the CHT at 2 dpt. Two-way ANOVA with Tukey?s HSD post hoc test, **, p?<?0.01 compared to CTRL at 1 dpt, #, p?<?0.05 compared to CTRL at 2 dpt. Scale bar, 5?�m. g Schematic showing that apoptosis in the brain is associated with leukocyte distribution. h?k il1b mutation rescued the increased number of AO?+?or TUNEL?+?apoptotic cells in the zebrafish brain at 1 dpi. Two-way ANOVA with Tukey?s HSD post hoc test, **, p?<?0.01 compared to CTRL. Scale bar, 40?�m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT il1b^phk2/phk2
Condition:	amputation: caudal fin
Observed In:	brain apoptotic process brain cell caudal hematopoietic tissue macrophage
Stage:	Day 4

Phenotype Detail

Acknowledgments

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