FIGURE

Figure 7

ID

ZDB-FIG-220801-141

Publication

Hawkey-Noble et al., 2022 - Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis

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Figure 7

Differential gene expression in forkhead mutants. foxl1^-/- (A), foxc1a^-/- (C), and foxc1b^-/- (D) embryos at 6 dpf using TaqMan RT-qPCR to confirm genes of interest from RNA-Seq screen. Targets of interest were examined at 10 dpf in foxl1 mutants (B), demonstrating a recovery in gene expression. Fold change between WT and foxl1^-/- plotted with WT values set to 1 (* p < 0.05, ** p < 0.01, *** p < 0.001).

Expression Data

Genes:	col1a1a col1a1b col11a2 hbae3 hpxa matn1 sp7
Fish:	AB foxc1a^{ua1017/ua1017} (AB) foxc1b^{ua1018/ua1018} (AB) foxl1^nfl1/nfl1 (AB)
Anatomical Term:	whole organism
Stage Range:	Day 6 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxc1a^{ua1017/ua1017} (AB) foxc1b^{ua1018/ua1018} (AB) foxl1^nfl1/nfl1 (AB)
Observed In:	whole organism
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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