Gene
sp7
- ID
- ZDB-GENE-040629-2
- Name
- Sp7 transcription factor
- Symbol
- sp7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables promoter-specific chromatin binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including cranial suture morphogenesis; dentinogenesis; and osteoblast differentiation. Is expressed in several structures, including bone element; ectoderm; fin; head; and optic primordium. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 79 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu605 (29 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 12 | Alliance | Osteogenesis imperfecta, type XII | 613849 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:Q6U1J4 | InterPro | 440 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available