Gene
hpxa
- ID
- ZDB-GENE-030131-5773
- Name
- hemopexin a
- Symbol
- hpxa Nomenclature History
- Previous Names
-
- hpx a
- hpx
- wu:fi17f11
- wu:fi19a10
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood; liver; and male organism. Orthologous to human HPX (hemopexin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1444 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30920 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31729 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41460 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Heme transport and cell adhesion protein | Hemopexin | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PHG2 | InterPro | 447 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-145P14 | ZFIN Curated Data | |
| Encodes | EST | fi17f11 | ||
| Encodes | EST | fi19a10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6797476 | ||
| Encodes | cDNA | MGC:66092 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174011 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001111147 (1) | 2173 nt | ||
| Genomic | GenBank:CT030044 (1) | 148990 nt | ||
| Polypeptide | UniProtKB:Q6PHG2 (1) | 447 aa |
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Hawkey-Noble, A., Pater, J.A., Kollipara, R., Fitzgerald, M., Maekawa, A.S., Kovacs, C.S., Young, T.L., French, C.R. (2022) Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis. Genes. 13(7):
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Feng, J., Song, G., Wu, Y., Chen, X., Pang, J., Xu, Y., Shen, Q., Guo, S., Zhang, M. (2021) Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Food & function. 12(23):12087-12097
- Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Liu, W., Zheng, Y. (2018) Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 243:1904-1911
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Vettori, A., Greenald, D., Wilson, G.K., Peron, M., Facchinello, N., Markham, E., Sinnakaruppan, M., Matthews, L.C., McKeating, J.A., Argenton, F., van Eeden, F.J.M. (2017) Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. Proceedings of the National Academy of Sciences of the United States of America. 114(37):9948-9953
- Holowiecki, A., O'Shields, B., Jenny, M.J. (2016) Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicology and applied pharmacology. 311:74-87
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