FIGURE

Fig. 5

ID

ZDB-FIG-220629-27

Publication

Roca et al., 2022 - Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

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Fig. 5

Fig. 5. TNF-induced glutaminolysis increases succinate levels in mycobacterium-infected macrophages in a RIP3- and PGAM5-dependent manner.

(A and B) Quantification of succinate in zebrafish larvae 1 day after infection with Mm or mock-injected, that are wild-type or TNF^hi treated with GPNA, BPTES, or vehicle (A) and TNF^hi, TNF^hi RIP3 morphants, or TNF^hi PGAM5 morphants (B). Each point represents the mean of four independent experiments in (A) and two independent experiments in (B). Vertical bars denote pooled SD. ***P < 0.001, ****P < 0.0001 (one-way ANOVA with Tukey’s post-test); ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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