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Fig. 3

ID

ZDB-FIG-220629-25

Publication

Roca et al., 2022 - Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

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Fig. 3

Fig. 3. TNF increases succinate-dependent mROS in mycobacterium-infected macrophages.

(A and B) Quantification of mROS in larvae 1 day after infection with Mm that are wild-type or TNF^hi treated with atpenin A, TTFA, DM-malonate, or vehicle (A) or wild-type treated with succinate, DEBM, or vehicle. Horizontal bars denote means; *P < 0.05, **P < 0.01, ***P < 0.001,****P < 0.0001 [one-way ANOVA with Tukey’s post-test (A) or Dunn’s post-test (B)]. Black and red symbols in (B) represent uninfected (ui) and Mm-infected (Mm) macrophages, respectively, in the same animal. Data are representative of two or three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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