FIGURE

FIGURE 4

ID

ZDB-FIG-220325-12

Publication

Van Gils et al., 2022 - The Abcc6a Knockout Zebrafish Model as a Novel Tool for Drug Screening for Pseudoxanthoma Elasticum

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FIGURE 4

Schematic representation of the anti-mineralization effects of the tested compounds. For the compounds evaluated in the present study, the type of administration or absorption is mentioned in the top row, as well as the type of administration used in any mouse or human studies which were done with this compound. The anti mineralizing effects of the different compounds are shown, as well as where these effect take place in the cascade to form hydroxyapatite crystals. Finally, the differences between the hypermineralization in zebrafish and mammals with respect to abcc6a and ABCC6 deficiency are shown. Figure created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol