FIGURE

FIGURE 2

ID

ZDB-FIG-220325-10

Publication

Van Gils et al., 2022 - The Abcc6a Knockout Zebrafish Model as a Novel Tool for Drug Screening for Pseudoxanthoma Elasticum

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FIGURE 2

Compound treatment effects on the abcc6a^cmg52/cmg52 spinal hypermineralization phenotype. After semiquantification and statistical analysis, mean ± SD percentile values of the spinal mineralization were normalized per compound to the respective control values of the untreated abcc6a^cmg52/cmg52 fish. (A) 80 µM VK1 (58 ± 28) versus C (100 ± 48), 42% reduction (B) 20 µM STS (45 ± 40) versus C (100 ± 65), 55% reduction (C) 100 µM Etid. (65 ± 43) versus C (100 ± 67), 35% reduction (D) 100 µM Alen. (61 ± 39) versus C (100 ± 58), 39% reduction (E) 10 mM MgC (55 ± 27) versus C (100 ± 55), 45% reduction (F) 5 mM MgC (70 ± 42) versus C (100 ± 55), 30% reduction. Treatments resulted in significant reductions (*p < 0.05), except for 5 mM MgC.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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