FIGURE

Fig. 1

ID

ZDB-FIG-220324-46

Publication

Xiao et al., 2022 - Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

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Fig. 1

The tectal neuropil of larval zebrafish is interspersed with OPC processes but largely devoid of myelin.

a, Transgenic zebrafish showing OPC processes throughout the brain. Dashed line indicates cross-sectional plane shown in b and c. Schematic of zebrafish brain delineates RGC axons, dendrites of PVINs and OPCs in tectal neuropil. b, c, Cross-sectional views of transgenic zebrafish showing that OPC processes intersperse the tectal neuropil (dashed lines), whereas myelin is largely absent. Scale bars, 50 µm. d, Sub-projection of OPC reporter lines (dorsal view) stained with BODIPY to outline tectal neuropil (NP) and the periventricular neuron zone (PVN). Dashed lines indicate the border between NP and PVN. Scale bar, 40 µm. e, Time lapse of four individual OPCs (lateral rotation view). Dashed lines depict tectal NP. Scale bar, 20 µm. f, g, Quantifications of individual OPCs as shown in e, showing low rates of soma position changes, division and differentiation.

Expression Data

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Antibody Labeling

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Neurosci.