PUBLICATION
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
- Authors
- Xiao, Y., Petrucco, L., Hoodless, L.J., Portugues, R., Czopka, T.
- ID
- ZDB-PUB-220305-3
- Date
- 2022
- Source
- Nature Neuroscience 25(3): 280-284 (Journal)
- Registered Authors
- Czopka, Tim, Hoodless, Laura, Xiao, Yan
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology
- Cell Differentiation/physiology
- Myelin Sheath
- Oligodendrocyte Precursor Cells*
- Oligodendroglia/metabolism
- Superior Colliculi/physiology
- Zebrafish
- PubMed
- 35241802 Full text @ Nat. Neurosci.
Citation
Xiao, Y., Petrucco, L., Hoodless, L.J., Portugues, R., Czopka, T. (2022) Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Nature Neuroscience. 25(3):280-284.
Abstract
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping