FIGURE

Figure 3

ID

ZDB-FIG-220310-3

Publication

Varga et al., 2022 - Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates

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Figure 3

Application of the calibrated protocol to the acetylome to detect novel potential HDAC6 substrates. (A) Blue dots and yellow dots show the distribution of scores for acetylated peptides in the D-TRAINING set and the acetylome peptides (as annotated in the PhosphoSitePlus database), respectively. Boxplots are drawn between the 1st and 3rd quartiles of the data and whiskers extend by 1.5 times the interquartile range. (B, C) Sequence logos of (B) substrates from the D-EXTENDED set, and (C) top 100 peptides predicted by our protocol.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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