FIGURE

Figure 1

ID

ZDB-FIG-220131-324

Publication

Cheng et al., 2022 - Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis

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Figure 1

OP-B had more significant effect on inhibiting A549/DDP cells and its transplantation tumor growth than that in A549 cells. A. Chemical structure of OP-B. B. CCK8 assay tested the resistance index of A549/PTX (a) and A549/DDP (b) cells. C. Cell inhibition rate of NCI-H460, A549, A549/PTX and A549/DDP cells treated by OP-B for 24 (a) and 48 h (b). D. CCK8 assay tested inhibitory effect of OP-B combined with DDP on A549 and A549/DDP cells for 24 h. E. Changes of body weight in mice with A549 (a) and A549/DDP (b) transplantation tumor after treated with OP-B for 25 days. F. Changes of A549 (a) and A549/DDP (b) transplantation tumor volume after treated with OP-B for 25 days. G. Tumor inhibition rate of A549 (a) and A549/DDP (b) after treated with OP-B for 25 days. H. The comparison of tumor inhibition rate between A549 and A549/DDP xenograft after treated with OP-B for 25 days. The bars and error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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