FIGURE

Figure 4

ID

ZDB-FIG-211216-13

Publication

Kim et al., 2021 - The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19

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Figure 4

Tissue-specific up-regulation of ace2 expression by RAAS inhibitors. The ace2 expression was significantly increased in captopril and olmesartan treated groups compared to the DMSO control in the gill, heart, and kidney (n = 6 per gene-organ-drug combination, *p < 0.05, **p < 0.01, ***p < 0.001 unpaired t test). Olmesartan also increased ace2 expression in the intestine (n = 6, p < 0.05, unpaired t test). Aliskiren treatment significantly decreased the ace2 expression in the heart; captopril treatment decreased ace expression in the heart, intestine, and the kidney (n = 6, p < 0.05, unpaired t test). Olm: olmesartan, Cap: captopril, Ali: aliskiren, Amlo: amlodipine.

Expression Data

Genes:	ace ace2
Fish:	AB
Conditions:	chemical treatment by environment: aliskiren chemical treatment by environment: captopril chemical treatment by environment: olmesartan
Anatomical Terms:	gill heart intestine kidney
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: aliskiren chemical treatment by environment: captopril chemical treatment by environment: olmesartan
Observed In:	gill heart intestine kidney
Stage:	Adult

Phenotype Detail

Acknowledgments

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