Gene
ace2
- ID
- ZDB-GENE-041114-6
- Name
- angiotensin I converting enzyme 2
- Symbol
- ace2 Nomenclature History
- Previous Names
-
- zgc:92514 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable carboxypeptidase activity and metallopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in several cellular components, including apical plasma membrane; cilium; and extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb442 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| ihb449 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| sa1003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10138 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41865 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ace2 | Zebrafish Nomenclature Committee | |
| CRISPR2-ace2 | Zebrafish Nomenclature Committee | |
| CRISPR3-ace2 | Tyrkalska et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Collectrin domain | Peptidase M2, peptidyl-dipeptidase A |
|---|---|---|---|---|
| UniProtKB:A0A8M2BGN5 | InterPro | 807 | ||
| UniProtKB:E7F9E5 | InterPro | 818 | ||
| UniProtKB:Q5U380 | InterPro | 785 | ||
| UniProtKB:A0AB32TXH6 | InterPro | 783 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-226L13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92514 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007297 (1) | 2881 nt | ||
| Genomic | GenBank:CU652893 (1) | 54988 nt | ||
| Polypeptide | UniProtKB:E7F9E5 (1) | 818 aa |
- Wang, T., Lin, X., Li, Y., Lu, Y. (2023) Artificial Lipid Biomembranes for Full-Length SARS-CoV-2 Receptor. Advanced materials (Deerfield Beach, Fla.). 35:e2300575e2300575
- Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822
- Kraus, A., Huertas, M., Ellis, L., Boudinot, P., Levraud, J.P., Salinas, I. (2022) Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Brain, behavior, and immunity. 102:341-359
- Tyrkalska, S.D., Martínez-López, A., Arroyo, A.B., Martínez-Morcillo, F.J., Candel, S., García-Moreno, D., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V. (2022) Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science advances. 8:eabo0732
- He, L., Chen, Y., Hu, Z., Zhang, Y., Wang, Y., Wei, J., Fan, Z., Xu, J., Peng, M., Zhao, K., Zhang, H., Liu, C. (2021) Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 278:130349
- Kim, G.J., Melgoza, A., Jiang, F., Guo, S. (2021) The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19. Scientific Reports. 11:23670
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
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