Gene
ace
- ID
- ZDB-GENE-030131-1826
- Name
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Symbol
- ace Nomenclature History
- Previous Names
-
- fb81h03
- si:ch211-124e16.1
- wu:fb81h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have dipeptidyl-peptidase activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and nephritis (multiple). Is expressed in several structures, including adaxial cell; digestive system; endocrine system; eye; and pectoral fin. Orthologous to human ACE (angiotensin I converting enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Renal tubular dysgenesis | 267430 | ||
| [Angiotensin I-converting enzyme, benign serum increase] | |||
| {Microvascular complications of diabetes 3} | 612624 | ||
| {Myocardial infarction, susceptibility to} | |||
| {SARS, progression of} | |||
| {Stroke, hemorrhagic} | 614519 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001548 | Peptidase M2, peptidyl-dipeptidase A |
Domain Details Per Protein
| Protein | Length | Peptidase M2, peptidyl-dipeptidase A |
|---|---|---|
|
UniProtKB:E7FFA5
|
1324 |
Interactions and Pathways
No data available
Plasmids
No data available