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Figure 4 Tissue-specific up-regulation of ace2 expression by RAAS inhibitors. The ace2 expression was significantly increased in captopril and olmesartan treated groups compared to the DMSO control in the gill, heart, and kidney (n = 6 per gene-organ-drug combination, *p < 0.05, **p < 0.01, ***p < 0.001 unpaired t test). Olmesartan also increased ace2 expression in the intestine (n = 6, p < 0.05, unpaired t test). Aliskiren treatment significantly decreased the ace2 expression in the heart; captopril treatment decreased ace expression in the heart, intestine, and the kidney (n = 6, p < 0.05, unpaired t test). Olm: olmesartan, Cap: captopril, Ali: aliskiren, Amlo: amlodipine.