FIGURE

Figure 7

ID

ZDB-FIG-211201-206

Publication

Schmitner et al., 2021 - Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

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Figure 7

Photoreceptors are restored from neurod-expressing progenitors. (a?c) In neurod:GFP transgenics, strong GFP is detected mainly in the INL in controls, and in the INL and ONL of pdx1 mutants (a). In controls, neurod:GFP labeled rod-shaped cells in the ONL were observed. In pdx1^?/? mutants, neurod:GFP labeled rod and cone shaped cells in the ONL in most mutants (b,c, see Table 2). Sections were counterstained with DAPI (blue). A significant increase in GFP positive cells in the INL was detected in pdx1^?/? mutants (d). Box plot extends from 75% to 25%, whiskers showing minimum and maximum, line indicates median, n = 10 controls, 9 pdx1^?/?. Scale bar: 50 �m. (INL, inner nuclear layer; ONL, outer nuclear layer).

Expression Data

Gene:	EGFP
Fish:	nl1Tg pdx1^sa280/sa280; nl1Tg
Anatomical Terms:	retinal inner nuclear layer retinal outer nuclear layer retinal cone cell retinal outer nuclear layer retinal rod cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdx1^sa280/sa280; nl1Tg
Observed In:	retinal inner nuclear layer
Stage:	Adult

Phenotype Detail

Acknowledgments

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