FIGURE

Fig. 2

ID

ZDB-FIG-211103-85

Publication

Stewart et al., 2021 - longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth

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Fig. 2

Fin overgrowth in loft2 requires kcnh2a. (A,B) Bright-field images of clutchmate TL; kcnh2a+/+ (A) and TL; kcnh2ab1391/b1391 (B) adult zebrafish. Scale bars: 1 cm. (C-E) Representative images of regenerated caudal fins at 27 days post-amputation (dpa) from (C) wild-type control, (D) loft2/t2; kcnh2a+/+ and (E) loft2/t2; kcnh2ab1391/b1391 fish. The dashed yellow line indicates the site of fin resection. Scale bars: 1 mm. (F) Quantification of fin ray outgrowth of wild-type (blue circles), loft2/t2; kcnh2+/+ (red squares) and loft2/t2; kcnh2ab1391/b1391 (orange squares) fish at 27 dpa. Each data point represents the normalized length of ray 3 from an individual animal of the indicated genotype. ****P<0.005 (one-way ANOVA with Tukey's multiple comparisons tests). ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lof^t2/t2 kcnh2a^b1391/b1391; lof^t2/t2
Condition:	amputation: caudal fin
Observed In:	caudal fin
Stage:	Adult

Phenotype Detail

Acknowledgments

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