FIGURE

Figure 9

ID

ZDB-FIG-211002-10

Publication

Chebli et al., 2021 - The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish

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Figure 9

The appa^−/−appb^−/− 2 dpf larvae zebrafish exhibit smaller brain ventricle. Dorsal 3D surface rending of confocal stacks

taken from brain ventricles of dextran injected 2 dpf zebrafish larvae (A). Quantification of total ventricle surface area and volume show that both are decreased in appa^-/-appb^-/- larvae (B). Lateral 3D surface rending of confocal stacks from brain ventricles of dextran injected 2 dpf zebrafish larvae with close up on diencephalic ventricle (C). Quantification of surface area and volume of the diencephalic ventricle in WT and appa^-/-appb^-/- larvae (D). Measurement of gross ventricle morphology at 2dpf WT and appa^-/-appb^-/- larvae as the length (E). Distance between rostral to caudal, diencephalon ventricle sagittal length, amplitude and height show no significant difference in mutants (F). Data are reported as mean ± SEM. ** ρ < 0.01, **** ρ < 0.001. n: (B) WT = 19, appa^-/-appb^-/- = 34, (D) WT = 8, appa^-/-appb^-/- = 34, (F) WT = 5, appa^-/-appb^-/- = 4.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	appa^{zf3579/zf3579}; appb^{zf3355/zf3355} (AB)
Observed In:	third ventricle
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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