FIGURE

Figure 8

ID

ZDB-FIG-210930-15

Publication

Qi et al., 2021 - Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

Other Figures

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Figure 8

Carnosine and PK11195 can alleviate the effects caused by ACR on retinal hyaloid vasculature at 5 dpf. A) Representative confocal images of hyaloid vasculature. White scale bar: 20 µm. B) Quantification of hyaloid vasculature showed significant increasing numbers of branches in akr1a1a1^+/+ larvae incubated with 10 µm ACR but rescued by carnosine (dissolved in egg water) and PK11195 (dissolved in DMSO) at 5 dpf, n = 11–18. For statistical analysis one‐way ANOVA followed by Tukey's multiple comparisons test was applied. **p < 0.01, ****p < 0.001. NS, not significant. DMSO, dimethylsulfoxide. CAR, carnosine. PK, PK11195.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Conditions:	chemical treatment by environment: carnosine chemical treatment by environment: PK-11195 chemical treatment by environment: acrolein
Observed In:	hyaloid vessel hyaloid vessel sprouting angiogenesis
Stage:	Day 5

Phenotype Detail

Acknowledgments

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