FIGURE

Figure 2

ID

ZDB-FIG-210911-14

Publication

Ear et al., 2021 - A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

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Figure 2

GIV-L, a human transcript for GIV, translates a variant protein that contains a PBM.A, schematic of GIV and GIV-L transcript as annotated in ensembl. Indicated in red is region where transcript sequence of GIV (Exon 31) and GIV-L diverges. The panel below shows nucleotide sequence and translated sequence of indicated region. B, MeRIP-Seq analysis of GIV transcript as annotated in MeT-DB (http://compgenomics.utsa.edu/methylation/) to map degree of m6A-methylated RNA. Highlighted in red is the corresponding region of GIV-L transcript (the intron immediately downstream of exon 31) indicating the methylated region. C, reverse-transcription PCR of GIV and GIV-L transcript in multiple cell lines: DLD1 E-type and R-type (top), HCT116 (middle, left), Caco-2 (middle, right), and HeLa (bottom).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.