FIGURE

Figure 1

ID

ZDB-FIG-210902-108

Publication

Feng et al., 2021 - FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

FDA-approved drug screening on compounds boosting HSPCs expansion in zebrafish. (A) The immunofluorescent staining images of Tg(CD41-GFP) and Phospho-Histone H3 (PH3). White arrowheads indicate merged signals. (B) Statistical diagram of corresponding percentage of PH3⁺ cells in CD41-GFP ^low populations (2.5 dpf, 2.33 � 0.55; 3 dpf, 3.66 � 0.31; 3.5 dpf, 6.26 � 0.43; 4 dpf, 9.96 � 0.90; 6.78 � 0.90). (C) An overview of the experimental design in this study for drug screening by using zebrafish. A total of 20 wild-type embryos (3 dpf) were transferred to each well in a 12-well plate format. Then, embryos were administrated with one of 171 FDA-approved drugs for 24 h and screened for quantitative increases or decreases of signals in the CHT (caudal hematopoietic tissue) region at 4 dpf. The red box indicates the CHT region, and blue arrowheads indicate cmyb⁺ signals. Mean � SEM, n = 7; Scale bar, 50 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cells