FIGURE

Figure 5

ID

ZDB-FIG-210503-94

Publication

Ko et al., 2021 - Differential Regulation of Ca²⁺-Activated Cl^- Channel TMEM16A Splice Variants by Membrane PI(4,5)P₂

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Figure 5

TMEM16A(ac) current recovery from inhibition by PI(4,5)P₂ depletion. (A) Current traces for TMEM16A(ac) in control cells intracellularly perfused with 3 mM ATP (top), cells perfused with AMP-PNP (middle), and cells expressing PIPKI? with 3 mM ATP (bottom) before and after a +120 mV 1 s depolarizing pulse. TMEM16A(ac) currents were measured at +50 mV at the indicated times after the depolarizing pulse. Dotted lines indicate a zero current; dashed lines indicate the initial TMEM16A(ac) current before the depolarizing step. (B) Summary time courses of TMEM16A(ac) current recovery in response to PI(4,5)P₂ depletion by Dr-VSP activation (ATP, n = 6; AMP-PNP, n = 5; PIPKI?, n = 5).

Expression Data

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Acknowledgments

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