FIGURE

Fig. 5

ID

ZDB-FIG-210316-43

Publication

Gray et al., 2020 - Postembryonic screen for mutations affecting spine development in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

The kif6stl95 mutant displays early notochord bending and larval onset scoliosis with rotation, without obvious vertebral malformations. Bright field of representative sibling WT and mutant kif6stl95/stl95 phenotypes at 5 dpf (A) and mutant adult at 60 dpf (B). μCT imaging of a kif6stl95/stl95 mutant at 60 dpf (C). Region of homozygosity-based mapping graphed as mutant allele ratio over the total genomic distance shows a peak of homozygosity at Chromosome 17 (D). Multi-species alignment of the switch II domain of Kif6 proteins illustrating the amino acid change in the kif6stl95/stl95 mutant to Glutamine from a well-conserved Leucine residue (E). Scale bars (A), 1 mm and (B, C), 1 cm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kif6^stl95/stl95
Observed In:	axis vertebral column
Stage Range:	Day 5 to Days 45-89

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 471, Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L., Postembryonic screen for mutations affecting spine development in zebrafish, 18-33, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.