FIGURE

Fig. 5

ID

ZDB-FIG-210316-43

Publication

Gray et al., 2020 - Postembryonic screen for mutations affecting spine development in zebrafish

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Fig. 5

The kif6stl95 mutant displays early notochord bending and larval onset scoliosis with rotation, without obvious vertebral malformations. Bright field of representative sibling WT and mutant kif6stl95/stl95 phenotypes at 5 dpf (A) and mutant adult at 60 dpf (B). ?CT imaging of a kif6stl95/stl95 mutant at 60 dpf (C). Region of homozygosity-based mapping graphed as mutant allele ratio over the total genomic distance shows a peak of homozygosity at Chromosome 17 (D). Multi-species alignment of the switch II domain of Kif6 proteins illustrating the amino acid change in the kif6stl95/stl95 mutant to Glutamine from a well-conserved Leucine residue (E). Scale bars (A), 1 ?mm and (B, C), 1 ?cm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kif6^stl95/stl95
Observed In:	axis vertebral column
Stage Range:	Day 5 to Days 45-89

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 471, Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L., Postembryonic screen for mutations affecting spine development in zebrafish, 18-33, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.