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Fig 12

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ZDB-FIG-210304-17

Publication

Lu et al., 2021 - A novel role of Zebrafish TMEM33 in negative regulation of interferon production by two distinct mechanisms

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Fig 12

A model on the dual roles of zebrafish TMEM33 in negative regulation of RLR-mediated signaling pathways.

Upon virus infection, fish RIG-I senses the viral RNA and interacts with MAVS, leading to the recruitment of TBK1, which phosphorylates MITA and IRF3, then induces IFN production. TMEM33, an ER-localized protein, triggers the K48-linked ubiquitination and degradation of MAVS, meanwhile, it also reduces MITA/IRF3 phosphorylation by acting as a substrate of TBK1, thereby preventing IFN expression.

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