FIGURE

FIGURE 6

ID

ZDB-FIG-210103-28

Publication

Wu et al., 2020 - Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 6

Upregulation of hnf4a‐P1, downregulation of hnf4a‐P2, and increased expression of ddah1, 11b‐hsd1, asgr1, and tdo2a in zebrafish. Gene expression profiles of hnf4a‐P1, hnf4a‐P2, ddah1, 11b‐hsd1, zhi(asgr1), and tdo2a, in [HBx,src] and [HBx,scr,p53^−/+] transgenic fish with normal diet (NOR), diet‐induced obesity promoting HCC (DIO) and oligo‐fucoidan treatment (DIO+OF) were shown. Statistical significance was calculated by t‐test: *P ≤ .05, **P ≤ .01, ***P ≤ .001.

Expression Data

Genes:	asgrl1 ddah1 hnf4a hsd11b1lb tdo2a
Fish:	nn1002Tg; nn1003Tg tp53^zdf1/+; nn1002Tg; nn1003Tg
Conditions:	increased food availability chemical treatment by gavage: fucoidan, increased food availability
Anatomical Term:	whole organism
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1002Tg; nn1003Tg tp53^zdf1/+; nn1002Tg; nn1003Tg
Conditions:	increased food availability chemical treatment by gavage: fucoidan, increased food availability
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Clin Transl Med