FIGURE

FIGURE 1

ID

ZDB-FIG-210103-23

Publication

Wu et al., 2020 - Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

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FIGURE 1

Oligo‐fucoidan pre‐treatment reduced the expression of lipogenesis genes, fibrosis marker and decreased the levels of collagen fibers in adult [HBx,src] transgenic zebrafish. A, Expression of lipogenic factors (pparg, mlxip, and srebf1), B, lipogenic enzymes (agpat4, pap and fasn), and C, fibrosis markers (ctgfa, hpse, and col1a1a). Data are presented as dot plots, each dots represent one fish. Statistical significance was calculated by t‐test (*P ≤ .05, **P ≤ .01, ***P ≤ .001). D, Representative images and statistical analysis of Sirius Red stain in [HBx,src] transgenic fish. Scale bar represents 50 μm. WT represents non‐transgenic wild‐type control fish, WT+OF stands for WT fish feeding with OF, NOR indicates normal diet, DIO denotes diet‐induced obesity, DIO+OF represents DIO fish given oral gavage with 0.051 mg OF.

Expression Data

Genes:	agpat4 col1a1a ccn2a fasn hpse mlxip plpp1a pparg srebf1
Fish:	WT nn1002Tg; nn1003Tg
Conditions:	chemical treatment by gavage: fucoidan increased food availability chemical treatment by gavage: fucoidan, increased food availability
Anatomical Term:	whole organism
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT nn1002Tg; nn1003Tg
Conditions:	chemical treatment by gavage: fucoidan increased food availability chemical treatment by gavage: fucoidan, increased food availability
Observed In:	whole organism whole organism Collagen
Stage:	Adult

Phenotype Detail

Acknowledgments

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