FIGURE

Fig. 3

ID

ZDB-FIG-201202-9

Publication

Loontiens et al., 2020 - PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation

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Fig. 3

PHF6 controls the expression of hematopoietic lineage genes. (A,B) Gene Set Enrichment Analysis shows that an early B cell gene signature is significantly enriched at expense of (A) a myeloid gene signature (GSE24759) and (B) NK cell (CD56⁺CD16⁺CD3^–) gene signature (GSE24759) in short-term cultures of CD34⁺ progenitors on an OP9-GFP stromal feeder layer with stable PHF6 knockdown (GSE85373). (C,D) Gene Set Enrichment Analysis shows that an erythrocyte gene signature (C) but not a MEP gene signature (D) is significantly enriched at expense of a HSCs gene signature (GSE24759) in short-term cultures of CD34⁺ progenitors on an OP9-GFP stromal feeder layer with stable PHF6 knockdown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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