FIGURE

Figure 8

ID

ZDB-FIG-201107-26

Publication

Costa et al., 2020 - RAB13 mRNA compartmentalisation spatially orients tissue morphogenesis

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Figure 8

<italic>rab13</italic> mRNA polarisation orients blood vessel morphogenesis

Time‐lapse confocal microscopy of representative Tg(kdrl:EGFP) rab13^+/+ and rab13^{∆3′UTR/∆3′UTR} embryos. DLAV: dorsal longitudinal anastomotic vessel; HM: horizontal myoseptum.

Frequency of ISV ectopic branching occurring at the HM (n = 4 experiments; *P < 0.05; one‐way ANOVA with Bonferroni's correction).

Illustration of the role for RAB13 mRNA localisation, local translation and compartmentalisation of RAB13 function in defining the orientation of EC filopodia dynamics, motile EC polarity and blood vessel pathfinding.

Data information: T₀ = 25 hpf; arrowheads indicate extra branches emerging from the main ISVs at the HM position; scale bars = 50 μm (A). +/+, +/∆ and ∆/∆ represent Tg(kdrl:EGFP) rab13^+/+, rab13^+/∆3′UTR and rab13^{∆3′UTR/∆3′UTR} embryos, respectively (B). Bar chart is presented as means ± s.d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rab13^{umc203/umc203}; s843Tg
Observed In:	intersegmental vessel intersegmental vessel blood vessel morphogenesis
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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