FIGURE

Fig. 4

ID

ZDB-FIG-200903-9

Publication

Schumacher et al., 2020 - Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis

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Fig. 4

Fig. 4. itga4;itga5 double mutants have cardiovascular defects. (A) Schematic of Itga4 protein indicating the position of the premature stop codon at position 467 in the fifth ? propeller repeat. (B?D) Wild type, sibling, and itga4;itga5 double mutants at 28 hpf. (E?G) Wild type, sibling, and itga4;itga5 double mutants at 48 hpf. Sibling and double mutant embryos were obtained from an incross of itga4-/-;itga5+/? adults. Wild type embryos were obtained from separate crosses performed at the same time. Lateral views, arrowheads indicate pericardial edema. Scale bar is 200 ??m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	itga4^{sa14884/sa14884}; itga5^tbfe1/tbfe1
Observed In:	blood circulation head pericardial region whole organism
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 465(1), Schumacher, J.A., Wright, Z.A., Owen, M., Bredemeier, N.O., Sumanas, S., Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis, 46-57, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.