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Fig. 4 Fig. 4. itga4;itga5 double mutants have cardiovascular defects. (A) Schematic of Itga4 protein indicating the position of the premature stop codon at position 467 in the fifth β propeller repeat. (B–D) Wild type, sibling, and itga4;itga5 double mutants at 28 hpf. (E–G) Wild type, sibling, and itga4;itga5 double mutants at 48 hpf. Sibling and double mutant embryos were obtained from an incross of itga4-/-;itga5+/− adults. Wild type embryos were obtained from separate crosses performed at the same time. Lateral views, arrowheads indicate pericardial edema. Scale bar is 200 μm.
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Reprinted from Developmental Biology, 465(1), Schumacher, J.A., Wright, Z.A., Owen, M., Bredemeier, N.O., Sumanas, S., Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis, 46-57, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.