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Fig. 7

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ZDB-FIG-200617-8

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Navajas Acedo et al., 2019 - PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation

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Fig. 7

The PCP and Wnt pathways act in parallel to establish coordinated hair cell polarity and orientation in the neuromast. Model of how the PCP signaling genes Vangl2 and Scrib are required to establish individual polarity in the hair cells (left part of the box), while the Wnt pathway members Wnt11 (Wnt11f1), Gpc4 and Fzd7a/7b interact to establish coordinated support cell alignment (right part of the box) in primII-derived neuromasts. The coordinated alignment of support cells, which we assume have normal polarity because coordinated alignment is not disrupted in PCP signaling mutants, then dictates the individual hair cell orientation

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