Fig. s4

Comparison between the cell behaviors and hair cell phenotypes in the Wnt and PCP pathway mutants during development. a-f. Analyses of cell behaviors of hair cell precursors during development show no differences between Wild type and MZwnt11 (wnt11f1) mutants. a-b. Visual representation of the individual time lapses of hair cell formation in primll-derived neuromasts of Wild type (a) and MZwnt11 (wnt11f1) mutants (b). Each hair cell precursor (yellow) divides into two hair cells (red and blue) and either rearrange or not. c. Duration of the rearrangement that the hair cell progenitors undergo after division in wild type and MZwnt11 (wnt11f1) mutant embryos. d. Percentage of hair cell progenitors that undergo rearrangements after division in wild type and MZwnt11 (wnt11f1) mutant fish. e. Division angle with respect to the radius of each division event in hair cell progenitors of wild type and MZwnt11 (wnt11f1) mutant fish, and (f) the visual representation of each division event with respect to the XY axis. g. Histograms of angular data and von Mises fitted distribution (red) for the quantification of the alignment of each hair cell with respect to their closest neighbor during the development of primll-derived neuromasts in vang/2 and MZwnt11 (wnt11f1) mutant fish at 4 and 5dpf. Note how none of the conditions, except for MZwnt11 (wnt11f1) at 5dpf show coordination of the alignment of their hair cells with respect to their neighbor (Uniform distribution p-values for vang/2 at 4dpf=0.733, vang/2 at 5dpf=0.S12, MZwnt11 (wnt11f1) at 4dpf=0.066, MZwnt11 (wnt11f1) at 5dpf=1.46 x 10^-04). N.S = Not significant. *** p-value < 0.01.