FIGURE

Fig. 5

ID

ZDB-FIG-200414-10

Publication

Ali et al., 2019 - Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris

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Fig. 5

Development of choriocapillaris is dependent on VEGF-VEGFR2 in zebrafish. A: Confocal micrographs of the choriocapillaris of 5 days post fertilization (dpf) embryos from wildtype (WT), VHL mutant (VHL-/-), hif1aa-/-;hif1ab-/- (HIF1a-/-), Vegfr2b-/- (kdr -/-), Vegfr2a-/- (kdrl -/-) or fli1a:EGFP; Hsp70:Vegfaa-DN zebrafish incubated for 1 h at 37 °C daily from 1 to 5 dpf (Vegfaa-DN) crossed onto the Fli1a:EGFP background (endothelium shown in green). Yellow arrowheads indicate interstitial foci. Size bars indicates 20 μm in each image. B: Quantification of the number of interstitial foci in the experiment shown in A. n = 10–15 embryos, ***:p < 0.001. ns: non-significant.

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Acknowledgments

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Reprinted from Developmental Biology, 457(2), Ali, Z., Cui, D., Yang, Y., Tracey-White, D., Vazquez-Rodriguez, G., Moosajee, M., Ju, R., Li, X., Cao, Y., Jensen, L.D., Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris, 206-214, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.