ZFIN Image: Ali et al., 2019, Fig. 5

Image

Figure Caption

Fig. 5 Development of choriocapillaris is dependent on VEGF-VEGFR2 in zebrafish. A: Confocal micrographs of the choriocapillaris of 5 days post fertilization (dpf) embryos from wildtype (WT), VHL mutant (VHL-/-), hif1aa-/-;hif1ab-/- (HIF1a-/-), Vegfr2b-/- (kdr -/-), Vegfr2a-/- (kdrl -/-) or fli1a:EGFP; Hsp70:Vegfaa-DN zebrafish incubated for 1?h?at 37?�C daily from 1 to 5 dpf (Vegfaa-DN) crossed onto the Fli1a:EGFP background (endothelium shown in green). Yellow arrowheads indicate interstitial foci. Size bars indicates 20??m in each image. B: Quantification of the number of interstitial foci in the experiment shown in A. n = 10?15 embryos, ***:p < 0.001. ns: non-significant.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 457(2), Ali, Z., Cui, D., Yang, Y., Tracey-White, D., Vazquez-Rodriguez, G., Moosajee, M., Ju, R., Li, X., Cao, Y., Jensen, L.D., Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris, 206-214, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.