FIGURE

Fig. 9

ID

ZDB-FIG-200413-40

Publication

Taler et al., 2019 - Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate

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Fig. 9

col4a5^s510 embryos show the same TGF?-driven lens phenotype as plod3 mutants. (A,B) Live 4 dpf normal (A) and col4a5^s510/s510 (B) embryos. (n?>?100 embryos). (C,D) Transverse histological sections of eyes from 3.5 dpf normal (C) and col4a5^s510/s510 (D) embryos. (n?=?10 eyes from each genotype). (E,F) Live 4 dpf normal (E) (n?=?6) and col4a5^s510/s510 (F) (n?=?5) embryos, treated with SB-431542 from 30 hpf. (G,H) Transverse histological sections from eyes of the same normal and mutant embryos in G and H, respectively. Numbers of eyes analyzed: G?=?12, H?=?9. A,B,E,F are dorsal views, anterior to left, arrows point at lenses. Scale bars in A,B,E,F are 100??m and in C,D,G,H 20??m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT col4a5^s510/s510
Condition:	chemical treatment by environment: SB 431542
Observed In:	inner ear lens lens epithelium whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 458(2), Taler, K., Weiss, O., Rotem, S., Rubinstein, A.M., Seritrakul, P., Gross, J.M., Inbal, A., Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate, 177-188, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.