FIGURE

Figure 5

ID

ZDB-FIG-200406-28

Publication

Schmid et al., 2020 - Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium

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Figure 5

Copper fails to protect against cadmium-induced hair cell death. (A) At doses of 0.5 μM and higher copper sulfate caused significant hair cell death on its own. ****p < 0.0001 by Two-Way ANOVA and Šídák multiple comparisons test as compared to the 0-copper sulfate control. Using copper sulfate in concentrations up to 1 μM failed to protect against hair cell death in response to 30 μM of cadmium chloride. (B) The 0.25 μM dose of copper sulfate failed to show a significant reduction in hair cell death at all cadmium chloride doses tested. Data are displayed as mean ± standard deviation. n = 10 fish for all groups. (C) Representative images of the O2 Neuromast in control (top) and copper sulfate treated (bottom) fish following treatment with either 0 (left) or 60 (right) μM cadmium chloride.

Expression Data

Antibody:	Ab6-pvalb
Fish:	AB
Condition:	chemical treatment by environment: cadmium dichloride
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: cadmium dichloride
Observed In:	neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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