FIGURE

Figure 1

ID

ZDB-FIG-200406-24

Publication

Schmid et al., 2020 - Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium

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Figure 1

Cadmium kills hair cells in zebrafish larvae in a dose-dependent manner. (A) Treating 5-days post-fertilization (dpf) zebrafish with cadmium chloride doses ranging from 0 to 120 μM for 3 h showed an increasing amount of hair cell death with increasing cadmium chloride dose. Data are displayed as mean ± standard deviation. ****p < 0.0001 as compared to 0 μM cadmium chloride control by ANOVA and Dunnett’s post hoc test. Fish were fixed and stained with an anti-parvalbumin antibody and hair cells from six neuromasts from each fish were counted (OP1, M2, IO4, O2, MI2, and MI1) and averaged. n = 10 fish for the 0, 15, 60 and 120 μM cadmium chloride groups and n = 7 for the 30 μM cadmium chloride group. (B) Representative images of the MI1 neuromast following treatment with either 0 (left) or 60 (right) μM cadmium chloride.

Expression Data

Antibody:	Ab6-pvalb
Fish:	AB
Condition:	chemical treatment by environment: cadmium dichloride
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: cadmium dichloride
Observed In:	neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.