ZFIN Image: Schmid et al., 2020, Figure 1

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Figure Caption

Figure 1

Cadmium kills hair cells in zebrafish larvae in a dose-dependent manner. (A) Treating 5-days post-fertilization (dpf) zebrafish with cadmium chloride doses ranging from 0 to 120 μM for 3 h showed an increasing amount of hair cell death with increasing cadmium chloride dose. Data are displayed as mean ± standard deviation. ****p < 0.0001 as compared to 0 μM cadmium chloride control by ANOVA and Dunnett’s post hoc test. Fish were fixed and stained with an anti-parvalbumin antibody and hair cells from six neuromasts from each fish were counted (OP1, M2, IO4, O2, MI2, and MI1) and averaged. n = 10 fish for the 0, 15, 60 and 120 μM cadmium chloride groups and n = 7 for the 30 μM cadmium chloride group. (B) Representative images of the MI1 neuromast following treatment with either 0 (left) or 60 (right) μM cadmium chloride.

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