FIGURE

Fig. 6

ID

ZDB-FIG-200302-12

Publication

Fazilaty et al., 2019 - A gene regulatory network to control EMT programs in development and disease

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Fig. 6

Snail1 and Prrx1 are sequentially expressed during EMT. a qPCR assay showing the expression of prrx1a/b and snail1a/b (left) and premiRNAs (right) in zebrafish embryos after different treatments with BMP (n = 8). Asterisks indicate significant p value in one-way ANOVA with Bonferroni’s multiple comparison test compared to the control. (*p < 0.05, **p < 0.01 and ***p < 0.001). Source data are provided as a Source Data file. b Dorsal view of HH9 chicken embryos showing SNAIL1 and PRRX1 expression in control embryos and at different times after BMP-soaked bead implantation. c Transverse sections of E8.5 DES-EGFP reporter mouse embryos showing IFs for GFP and Snail1 (upper panel) or Prrx1 (lower panel). Insets show higher magnification pictures for GFP and Snail1 (1 and 2), or for GFP and Prrx1 (3 and 4). d Schematic model of the gene regulatory network. DES downstream enhancer of Snail1, PNC premigratory neural crest shown by arrows, MNC migratory neural crest. Scale bars: 100 μm. Scale bars: 100 μm for sections and 10 μm for insets (boxes 3–4)

Expression Data

Genes:	prrx1a prrx1b snai1a snai1b
Fish:	AB
Condition:	chemical treatment by environment: agonist
Anatomical Term:	cranial neural crest
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: agonist
Observed In:	cranial neural crest cranial neural crest miRNA transcription
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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