Gene
prrx1b
- ID
- ZDB-GENE-030131-9033
- Name
- paired related homeobox 1b
- Symbol
- prrx1b Nomenclature History
- Previous Names
-
- phox1 (1)
- fa97b09
- wu:fa97b09
- zgc:64199
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in cranial skeletal system development and positive regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Orthologous to human PRRX1 (paired related homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from de Bakker et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
agnathia-otocephaly complex | Alliance | Agnathia-otocephaly complex | 202650 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired mesoderm homeobox protein 1/2 |
---|---|---|---|---|---|---|
UniProtKB:A0A8M2B7I0
|
240 | |||||
UniProtKB:Q6P295
|
245 | |||||
UniProtKB:A0A8M6YUR5
|
267 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
prrx1b-201
(1)
|
Ensembl | 2,766 nt | ||
mRNA |
prrx1b-202
(1)
|
Ensembl | 943 nt |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg1(prrx1b:EGFP) |
|
| 2 | (3) | |
Tg2(prrx1b:EGFP) |
|
| 2 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-214D2 | ZFIN Curated Data | |
Encodes | EST | fa97b09 | ||
Encodes | cDNA | MGC:64199 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200050 (1) | 2818 nt | ||
Genomic | GenBank:CU571309 (1) | 108092 nt | ||
Polypeptide | UniProtKB:A0A8M6YUR5 (1) | 267 aa |
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Tessadori, F., de Bakker, D.E.M., Barske, L., Nelson, N., Algra, H.A., Willekers, S., Nichols, J.T., Crump, J.G., Bakkers, J. (2020) Zebrafish prrx1a mutants have normal hearts. Nature. 585:E14-E16
- Fazilaty, H., Rago, L., Kass Youssef, K., Ocaña, O.H., Garcia-Asencio, F., Arcas, A., Galceran, J., Nieto, M.A. (2019) A gene regulatory network to control EMT programs in development and disease. Nature communications. 10:5115
- Rago, L., Castroviejo, N., Fazilaty, H., Garcia-Asencio, F., Ocaña, O.H., Galcerán, J., Nieto, M.A. (2019) MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Developmental Cell. 51:446-459.e5
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5
- Tucker, N.R., Dolmatova, E.V., Lin, H., Cooper, R.R., Ye, J., Hucker, W.J., Jameson, H.S., Parsons, V.A., Weng, L.C., Mills, R.W., Sinner, M.F., Imakaev, M., Leyton-Mange, J., Vlahakes, G., Benjamin, E.J., Lunetta, K.L., Lubitz, S.A., Mirny, L., Milan, D.J., Ellinor, P.T. (2017) Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.. Circulation. Cardiovascular genetics. 10(5)
- Barske, L., Askary, A., Zuniga, E., Balczerski, B., Bump, P., Nichols, J.T., Crump, J.G. (2016) Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genetics. 12:e1005967
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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