Gene

prrx1b

ID
ZDB-GENE-030131-9033
Name
paired related homeobox 1b
Symbol
prrx1b Nomenclature History
Previous Names
  • phox1 (1)
  • fa97b09
  • wu:fa97b09
  • zgc:64199
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in cranial skeletal system development and positive regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Orthologous to human PRRX1 (paired related homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from de Bakker et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
b1247Allele with one deletionUnknownFrameshift, Premature StopCRISPR
el491Allele with one insertionUnknownFrameshift, Premature StopTALEN
sa37097Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Human Disease
Associated With prrx1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agnathia-otocephaly complex Alliance Agnathia-otocephaly complex 202650
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Associated With prrx1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003654 OAR domain
Family IPR043378 Paired mesoderm homeobox protein 1/2
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain OAR domain Paired mesoderm homeobox protein 1/2
UniProtKB:A0A8M2B7I0 240
UniProtKB:Q6P295 245
UniProtKB:A0A8M6YUR5 267
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prrx1b-201 (1) Ensembl 2,766 nt
mRNA prrx1b-202 (1) Ensembl 943 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg1(prrx1b:EGFP)
  • prrx1b
  • Danio rerio
2 (3)
Tg2(prrx1b:EGFP)
  • prrx1b
  • Danio rerio
2 (3)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-214D2ZFIN Curated Data
EncodesESTfa97b09
EncodescDNAMGC:64199ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPRRX11
Conserved genome location (synteny) (2)
Nucleotide sequence comparison (1)
Amino acid sequence comparison (2)
Citations
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