Gene

prrx1b

ID
ZDB-GENE-030131-9033
Name
paired related homeobox 1b
Symbol
prrx1b Nomenclature History
Previous Names
  • phox1 (1)
  • fa97b09
  • wu:fa97b09
  • zgc:64199
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cranial skeletal system development and positive regulation of gene expression. Predicted to localize to nucleus. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from de Bakker et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prrx1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agnathia-otocephaly complex Alliance Agnathia-otocephaly complex 202650
Associated With prrx1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003654 OAR domain
Family IPR043378 Paired mesoderm homeobox protein 1/2
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain OAR domain Paired mesoderm homeobox protein 1/2
UniProtKB:A0A8M2B7I0 240
UniProtKB:Q6P295 245
UniProtKB:A0A8M6YUR5 267
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prrx1b-201 (1) Ensembl 2,766 nt
mRNA prrx1b-202 (1) Ensembl 943 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations