FIGURE

Figure EV2

ID

ZDB-FIG-200212-38

Publication

Ki et al., 2019 - CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation

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Figure EV2

Depletion of ccp5 leads to defects in the sprouting angiogenesis

Blood vessels were observed in ccp5 AUG MOs (2–5 ng/nl)‐injected Tg(kdrl:eGFP) zebrafish at 40 hpf by fluorescent microscopy. Asterisks and arrowheads indicate impaired ISVs and DLAVs, respectively. Scale bars, 100 μm.

B–D

Quantification of the numbers of embryos with defective ISVs in (B), the numbers of embryos with aberrant DLAVs in (C), and the numbers of ruptured DLAVs in (D) from data observed in equivalent fields of view (within eight somites). Data are shown as median of three independent experiments with ≥ 20 embryos per condition. Statistical significance was determined using the Brown–Forsythe ANOVA followed by Dunnett's T3 post hoc test (***P < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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