ZFIN Image: Ki et al., 2019, Figure EV2

Image

Figure Caption

Figure EV2 Depletion of ccp5 leads to defects in the sprouting angiogenesis

A

Blood vessels were observed in ccp5 AUG MOs (2–5 ng/nl)‐injected Tg(kdrl:eGFP) zebrafish at 40 hpf by fluorescent microscopy. Asterisks and arrowheads indicate impaired ISVs and DLAVs, respectively. Scale bars, 100 μm.

B–D

Quantification of the numbers of embryos with defective ISVs in (B), the numbers of embryos with aberrant DLAVs in (C), and the numbers of ruptured DLAVs in (D) from data observed in equivalent fields of view (within eight somites). Data are shown as median of three independent experiments with ≥ 20 embryos per condition. Statistical significance was determined using the Brown–Forsythe ANOVA followed by Dunnett's T3 post hoc test (***P < 0.001).

Acknowledgments

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