FIGURE

Figure 6

ID

ZDB-FIG-191230-800

Publication

Imle et al., 2019 - ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing

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Figure 6

Adpgk regulates glucose metabolism in zebrafish embryos. (a) Quantification of whole body glucose content and insulin expression in wild type, KD1, and KD2 embryos. N = 6 independent experiments, stage 22 hpf. (b) Ratio of lactate to pyruvate in wild type, KD1, and KD2 embryos. N = 3 independent experiments, stage 22 hpf. (c) Scheme of changes in high mannose glycans, complex- and hybrid-type glycans in KD1 compared to control embryos (stage 22 hpf) analyzed by HILIC-FLR-MS. * p < 0.05, ** p < 0.01, ***p < 0.005.

Expression Data

Gene:	ins
Fish:	AB + MO1-adpgk
Knockdown Reagent:	MO1-adpgk
Anatomical Term:	whole organism
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-adpgk AB + MO2-adpgk
Knockdown Reagents:	MO1-adpgk MO2-adpgk
Observed In:	whole organism whole organism glucose
Stage Range:	26+ somites to Prim-5

Phenotype Detail

Acknowledgments

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