FIGURE

Figure 6

ID

ZDB-FIG-191230-1775

Publication

Harris et al., 2019 - Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

Predicted structural differences in the FK1 proline-rich loop. Homology modeling was used to generate predicted models of DrFKBP52 and DrFKBP52-A111V, in the comparison to human FKBP52 and FKBP51 to determine conformational changes induced by the DrFKBP52-A111V mutation. Crystal structures of HsFKBP51 (PDB ID: 1KT0), HsFKBP52 (PDB ID: 1Q1C), DrFKBP52 (predicted), and DrFKBP52-A111V (predicted) are aligned; the respective FK1 domains are shown in space-filled modeling and colored in hydrophobicity scale (blue = hydrophilic, red = hydrophobic). Note that the only differences between FKBP51 and HsFKBP52 within the loop region are at positions 119 and 124.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.